Pharmaco4All test – a new generation pharmacogenomic test

Application of pharmacogenomics in therapy optimization

The development of personalized medicine allows for the adaptation of therapeutic procedures to individual patient characteristics. The way individuals respond to drugs can differ significantly due to genetic variations that affect pharmacokinetics and pharmacodynamics. In order to increase the safety and effectiveness of pharmacotherapy, St. Catherine Specialty Hospital conducts pharmacogenomic testing called Pharmaco4All, which is based on whole-genome sequencing (WGS).

The Pharmaco4All test reveals how your genetics affect the metabolism and action of the drugs you are currently taking or may take in the future. This helps doctors make optimal therapeutic decisions for each patient - without guesswork and without unnecessary risks of developing harmful side effects of drugs.

What does Pharmaco4All test analyze? 

Unlike traditional pharmacogenomic panels that include a limited number of genes, Pharmaco4All uses a whole-genome analysis, allowing the analysis of:

• key genes involved in drug metabolism, with an emphasis on those with the highest clinical level of evidence (1A). See a detailed list of drugs.

• genetic variants that can affect drug efficacy, as well as increase the risk of side effects and toxic reactions, thus ensuring more precise and safer drug selection.

The testing includes genes associated with drugs from the following groups: 

• pain relievers and anti-inflammatory drugs (analgesics and anti-inflammatory drugs)
• drugs that affect the digestive system (gastrointestinal drugs)
• drugs that affect the blood and blood-forming organs
• drugs that affect the heart and blood vessels (cardiovascular drugs)
• drugs for the treatment of systemic infections (antimicrobials)
• drugs for the treatment of malignant diseases and immunomodulators (oncological drugs)
• drugs that affect the musculoskeletal system
• drugs that affect the nervous system (psychiatric and neurological drugs)
• drugs for the endocrine system (endocrinological drugs)
• drugs for the treatment of infections caused by parasites
• drugs that affect the respiratory system (pulmonological drugs)

Thanks to WGS analysis, this test provides a comprehensive, permanent and scientifically based assessment of the pharmacogenomic profile of each patient.

Where and how can you get tested? 

Pharmaco4All test is performed at St. Catherine Specialty Hospital, which provides top-notch laboratory and bioinformatics processing.

Testing steps: 

1) Making an appointment

2) Counseling and informing about the test

3) Peripheral blood sample collection for analysis

4) Pharmacogenomic analysis in the laboratory

5) Clinical interpretation of the results in the form of a written report

The entire process takes an average of 4 to 5 weeks. Thanks to the application of new technology based on WGS analysis, the results are permanently applicable, because the genetic record does not change. Since a comprehensive analysis has been conducted, it is possible to perform additional repeated pharmacogenomic profile analyses for new drugs of evidence level 1A in the future, without the need for repeated blood sampling, in line with the progress of scientific research.

Additional options (possible with surcharge): 

1. Oral interpretation of the results by a doctor (an appointment can be arranged later after the results are received)

2. It is possible to arrange additional genetic testing from the same blood sample, including nutrigenetic testing, testing for hereditary diseases (such as hereditary risk of cancer, heart disease and other hereditary disorders)

For whom is this test intended? 

The Pharmaco4All test is intended for anyone who wants safer, more effective and personalized therapy, but especially for:

• patients with multiple chronic diagnoses who use multiple medications (polytherapy)
• people who have previously had side effects from medications
• before introducing psychiatric, cardiological or oncological therapy
• when changing therapy that did not give the expected effect
• healthy people who want to know preventively how they will react to certain medications

What are the advantages of the Pharmaco4All test? 

• Avoidance of unwanted side effects and toxic reactions
• Faster therapeutic response and reduction of “trial and error” time
• Permanent value of the results – valid for a lifetime
• Optimization of therapy in accordance with the latest clinical guidelines
• Compliance with the principles of precision medicine and patient safety

Pharmaco4All represents the gold standard in modern pharmacogenomics. Using a whole-genome analysis, this test brings a new level of safety and personalization to your treatment.

Available at the St. Catherine Specialty Hospital, Pharmaco4All is your first step towards a therapy that truly suits you.