Collagen biostimulators
How to restore collagen and naturally rejuvenate your skin?
Collagen biostimulators are an innovative solution for skin rejuvenation and regeneration. They work by stimulating the natural production of collagen, improving skin firmness, elasticity, and volume.
These treatments provide long-lasting results, making the skin firmer, more hydrated, and healthier-looking. They are an ideal choice for those who want a naturally refreshed and youthful appearance without invasive procedures. Discover the power of treatments that can be done during your lunch break and restore your skin’s youthful vitality!

Have you heard about polynucleotides?
Polynucleotides are DNA fragments, the main molecules that made up the genome, and they are used for various purposes in skincare treatments. Polynucleotides represent an innovative treatment in aesthetic medicine as they promote skin regeneration, provide deep hydration, and restore lost volume by strengthening its structure. These molecules are commonly found in creams, serums, and other skincare products, as they stimulate collagen and elastin synthesis—key proteins responsible for skin firmness and elasticity. Collagen and elastin maintain the skin smooth and healthy, but their natural production decreases with age, leading to reduced elasticity and the appearance of wrinkles. At St Catherine Skin Clinic, we use PDRN + Niacinamide, an advanced product combining two powerful ingredients designed to enhance skin health and appearance through targeted cellular action.
Key features of the product include:
- PDRN (Polydeoxyribonucleotide) – a nucleotide polymer derived from salmon DNA that stimulates cell growth, regeneration, and signaling.
- Niacinamide – a vitamin B3 derivative that reduces inflammation, controls sebum production, and improves skin texture.
- Combination with HA Solution – hyaluronic acid with three molecular weights for optimized skin biostimulation.
Benefits of this product include: stimulating cellular regeneration; activating collagen and elastin synthesis; deep skin hydration; reducing wrinkles and fine lines; soothing skin irritations; evening out skin tone and texture and strengthening the skin barrier. The product can be applied to the face, neck, décolleté, and hands using various techniques, including mesotherapy, fractional laser with drug delivery, or microneedling with radiofrequency. Clinical studies show that the combination of PDRN and hyaluronic acid has excellent effects on fibroblast function compared to using PDRN alone.
Sculptra® - a revolution in collagen production?
Sculptra® is the most powerful collagen stimulator, helping build up to 65% of new collagen. It contains Poly-L-Lactic Acid, a biocompatible and biodegradable substance that strongly stimulates collagen production in the skin. It is specially designed for both women and men who want to maintain their skin naturally without looking "over-volumized."
Micro-particles of Poly-L-Lactic Acid are injected into the deeper layers of the skin, where they promote collagen renewal and enhance skin structure. Over time, they stimulate the production of new collagen, particularly type 1 collagen, restoring skin firmness, quality, and volume.

For long-lasting results, 2-3 treatments are recommended. The good news is that you can return to your daily activities immediately after the procedure, while potential side effects such as swelling or bruising are mild and typically subside within a few days. The key advantage of Sculptra is its long-lasting results—up to 2 years
Sunekos - a breakthrough in natural skin rejuvenation
Sunekos is a 5th-generation injectable biostimulator, representing a major breakthrough in natural skin rejuvenation and quality improvement. The treatment is safe, fast, and effective, delivering both immediate and long-term results. It is ideal for everyone, regardless of age or skin type, and perfectly adapts to different skin conditions for both men and women:
- deep hydration
- restoring skin radiance
- smoothing fine lines
- reducing dark circles under the eyes
- regenerating sun-damaged skin
- evening out skin tone and reducing hyperpigmentation
- improving skin firmness and elasticity
Sunekos consists of non-crosslinked hyaluronic acid and six carefully selected amino acids (Glycine, L-Proline, L-Leucine, L-Lysine HCl, L-Valine, and L-Alanine), which stimulate the production of type IV and type VII collagen. Its effectiveness is clinically proven. The procedure takes only about 20 minutes, requires no downtime, and patients can resume their daily activities within 30 minutes of the application. It can be used on the entire face, periocular area, forehead, neck, and décolleté.
Lenisna and Juvelook – unveiling natural beauty
Lenisna and Juvelook are the latest third-generation collagen stimulators with an advanced formulation of poly-D, L-lactic acid (PDLLA). In addition to PDLLA they also contain non-crosslinked hyaluronic acid, which provides an immediate feeling of refreshment and hydration to the treated skin after the procedure. These collagen stimulators have the same composition, but the difference lies in the concentration of the components.

Juvelook treatment is ideal for reducing fine lines and wrinkles on the face, neck, and décolleté, fine wrinkles around the eyes, atrophic scars, enlarged pores and stretch marks. It can also be used to improve skin firmness and thickness. This is an innovative 2-in-1 skinbooster that acts as both a collagen stimulator and a hydration enhancer. The treatment delivers quick results in terms of skin hydration while simultaneously stimulating collagen production for long-term skin rejuvenation. The recommended number of treatments depends on the indications, generally ranging from 1 to 6 sessions in 4 to 6 weeks.
Main benefits of Juvelook treatment:
- Natural skin rejuvenation
- Long-term collagen stimulation
- Minimally invasive procedure
- Safe and biocompatible materials
Lenisna is a hybrid filler and tissue stimulator designed for aesthetic medicine, especially for facial rejuvenation. It combines the immediate effects of hyaluronic acid (HA) with the long-term properties of poly-D,L-lactic acid (PDLLA), which stimulates collagen. It is a stimulator that does not provoke a strong inflammatory response or granulomas, while offering powerful and gradual restoration of a youthful appearance in a completely natural way. Indications for treatment include deep wrinkles, excess and sagging skin on the face, neck and body. Lenisna can also be used for subtle volume enhancement on the face and body, as well as for the reduction of cellulite. It is also an excellent solution for signs of skin aging on the hands.
The recommended number of treatments varies depending on the indication, typically ranging from 3 to 6 sessions.
The first effect is visible immediately after the treatment due to the hydrating action of hyaluronic acid, while the most optimal results can be seen after one month when collagen synthesis begins. The full effect becomes apparent after six months. The main advantage of these collagen stimulators lies in the fact that no downtime is required and they simultaneously stimulate collagen and elastin synthesis.
Want to naturally combat premature signs of aging? Collagen biostimulators represent a major advancement in anti-aging treatments, offering multiple benefits in a single product. Book your appointment today!