Collagen biostimulators

How to restore collagen and naturally rejuvenate your skin?

Collagen biostimulators are an innovative solution for skin rejuvenation and regeneration. They work by stimulating the natural production of collagen, improving skin firmness, elasticity, and volume.

Have you heard about polynucleotides?

Polynucleotides are DNA fragments, the main molecules that made up the genome, and they are used for various purposes in skincare treatments. Polynucleotides represent an innovative treatment in aesthetic medicine as they promote skin regeneration, provide deep hydration, and restore lost volume by strengthening its structure. These molecules are commonly found in creams, serums, and other skincare products, as they stimulate collagen and elastin synthesis—key proteins responsible for skin firmness and elasticity. Collagen and elastin maintain the skin smooth and healthy, but their natural production decreases with age, leading to reduced elasticity and the appearance of wrinkles. At St Catherine Skin Clinic, we use PDRN + Niacinamide, an advanced product combining two powerful ingredients designed to enhance skin health and appearance through targeted cellular action.

Key features of the product include:

• PDRN (Polydeoxyribonucleotide) – a nucleotide polymer derived from salmon DNA that stimulates cell growth, regeneration, and signaling
• Niacinamide – a vitamin B3 derivative that reduces inflammation, controls sebum production, and improves skin texture
• Combination with HA Solution – hyaluronic acid with three molecular weights for optimized skin biostimulation

Sculptra® – a revolution in collagen production

Sculptra® is the most powerful collagen stimulator, building up to 65% of our new collagen. It contains poly-L-lactic acid, a biocompatible and biodegradable substance that strongly stimulates collagen production in the skin. It is especially intended for women and men who want to maintain their skin in a natural way, without looking “overfilled.”

Microparticles of poly-L-lactic acid are injected into the deeper layers of the skin, where they stimulate collagen renewal and improve skin structure. Over time, they promote the formation of new collagen, especially type I collagen, thereby restoring firmness, quality, and volume to the skin. For long-lasting results, 2–3 treatments are recommended. The good news is that after the treatment you can immediately return to your daily activities, while possible side effects such as swelling or bruising are mild and disappear within a few days. The key advantage of Sculptra is its longevity – results last up to 2 years.

Sunekos - a breakthrough in natural skin rejuvenation

Sunekos is a 5th-generation injectable biostimulator, representing a major breakthrough in natural skin rejuvenation and quality improvement. The treatment is safe, fast, and effective, delivering both immediate and long-term results. It is ideal for everyone, regardless of age or skin type, and perfectly adapts to different skin conditions for both men and women:

Radiesse – unique formula for skin rejuvenation

Radiesse is a biostimulator composed of calcium hydroxyapatite microspheres, a compound made of calcium and phosphate – minerals that naturally occur in our bones and teeth. Thanks to its unique composition, Radiesse allows for an individualized approach to the treatment, providing a double effect: as a dermal filler for replenishing volume while at the same time stimulating the natural processes of skin regeneration in order to preserve a youthful appearance.

Following treatment, Radiesse promotes the production of collagen and elastin, the key proteins responsible for skin firmness, elasticity and resistance of the skin. At the same time, it may help slow down the breakdown of existing collagen, supporting the long-term preservation of skin quality. Namely, as we age, the body’s natural collagen production gradually declines, while existing collagen reserves continue to break down. This leads to reduced skin elasticity, the appearance of wrinkles, skin laxity and volume loss. For this reason, biostimulators such as Radiesse offer an effective solution for individuals looking to improve skin quality from within and encourage its natural renewal.

Thanks to its versatility, Radiesse can be used as a collagen-stimulating filler to replenish lost volume and contour specific areas of the face, but also as a biostimulation treatment to improve skin texture, elasticity and overall quality. The treatment itself is quick, safe and with minimal recovery, and the effect is natural and progressive, making it ideal for patients seeking a subtle but long-lasting transformation.