Multi-dimensional omics approach to stratification patients with low back pain
St. Catherine Hospital is a part of colaborative scientific project "Multi-dimensional omics approach to stratification patients with low back pain" or "Pain-OMICS", founded by European Comission 7th framework programme (Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities) theme Health, dedicated to pain (Health. 2013.2.2.1-5 Understanding and controlling pain) in period 2013 - 2018. Pain-OMICS project involves 11 leading scientific and clinical centers across Europe, US and Australia and in Croatia partners are Specialty Hospital St. Catherine and Genos Ltd.
Low back pain as extremely prevalent disorder in western countries causing increasing disabilities, work absenteeism and lost productivity and inflicts substantial direct and indirect costs. Pain-OMICS project aims to identify new diagnostic and prognostic biomarkers to predict the transition from acute to chronic pain as well as molecular target sites for therapeutic interventions. In Europe, the incidence of low back pain varies between 5-11 %, while more than 40% of adults suffer from at least one episode of low back pain, causing beside clinical also socio-economical problem. Addressing the problem, Pain-OMICS group aims to find new way to characterize pathophysiology and identify new therapeutic targets of low back pain using complex system biology approaches– genomic, epigenomic, glycomic and activomic.
Pain-OMICS consortium consisted of leading international clinical centers and laboratories, coupled with research-intensive SMEs is in unique position to achieve this ambitious program, providing not only insight into molecular mechanisms of low back pain and discovery of predictive biomarkers, but also striving to transfer the knowledge for direct benefits for patients and provide more personalized approach.