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Centres of Excellence -> Obesity treatment -> Nutrigenetics - personalized nutrition and disease prevention

Nutrigenetics - personalized nutrition and disease prevention

Diet plan based on your DNA results.

Nutrigenetics is a field of genetics which connects genes and nutrition and enables personalized diet plans according to the patient's genetic profile, and simultaneously preventing the occurrence of certain diseases, or alleviating the symptoms if the disease has already occurred.

The Nutri4All nutrigenetic test analyzes over 100 different genes and non-coding regions of DNA. By analyzing  genes important for your diet, we can determine specific gene variants in your DNA which are responsible for the metabolism of certain food or supplements. According to the test results, each individual will get information on the metabolism of specific nutrients from food or supplement, in terms of normal or deficit metabolism respectively. Specific testing results enable us to choose the optimal nutrient supply, identify the poor detoxification of harmful substances in the liver, and indicate which foods you should avoid due to poor metabolism. By optimizing your diet based on your nutrigenetic status you can reduce or eliminate your risk of developing certain health conditions such as diabetes, obesity, cardiovascular disease (CVD), osteoporosis, hypertriglyceridemia (high levels of triglycerides in your blood) and chronic systemic inflammation.

Stress and a modern lifestyle led to some of the most common diseases today, such as diabetes, obesity and cancer. Some of them are caused by gene inheritance, but some of the diseases are caused by environmental factors. Regardless the reason we can prevent the occurrence of the disease with a healthy lifestyle, avoiding harmful environmental factors (smoking, unhealthy diet, sedentary lifestyle). Nutrigenetics reveals how specific changes in genes, and genetic variations can cause a harmful and undesirable effect on our body when eating certain food substances which lead to damage of tissues and organs and cause inflammation and diseases such as hereditary hypercholesterolemia, diabetes, phenylketonuria, celiac disease, obesity and cancer.

The nutrigenetic profile is determined by DNA analyses from the blood samples of each individual. The results of the analysis provide information for the optimization of individual diet plans, based on the needs of each person.

Nutrigenetic testing provides information on the metabolism of food substances that are considered beneficial for health. Using nutrigenetic testing we can also obtain information about the metabolism of fats (lipids), sugars (carbohydrates), homeostasis of glucose levels, metabolism of homocysteine and folate (vitamin B9), regulation of inflammatory conditions, detoxification mechanisms, oxidative stress, vitamin D metabolism and numerous other information.

With nutrigenetic testing, you can get information about:

  • Sugar (carbohydrate) metabolism, homeostasis of glucose levels, information on the risk of developing diabetes type 2 and nutritional advice on regulating the intake of certain types of carbohydrates that can reduce the risk of developing diabetes type 2
  • Lipid metabolism modulates the quantity and quality of ingested fats that will maintain cholesterol and triglycerides within interval values
  • Regulation of stress, sleep, energy and appetite and circadian rhythm (biological daily rhythm).
  • The metabolism of certain amino acids such as homocysteine, which in the case of elevated values, indicates the risk for cardiovascular diseases. To transform homocysteine into methionine and reduce the risk of disease development, folates are needed. A deficiency of folate (B9), vitamin B12, B6 can lead to hyperhomocysteinemia.
  • Genes and their protein products strictly control complex inflammatory processes, and thus defects in the genes that regulate inflammation can lead to a faulty inflammatory response that has a harmful effect on health.
  • The liver detoxification system is mediated by enzymes from the cytochrome P450 (CYP) family. Nutrigenetic testing enables the analysis of the CYP enzyme family and shows variations that affect the balance of detoxification of harmful intermediates of drugs and food substances in the liver.
  • Oxidative stress is responsible for cell, tissue and organ damage. It can cause diseases such as cancer, autoimmune diseases, cardiovascular diseases, diabetes and Alzheimer's disease. Nutrigenetic testing can identify genetic variations of the certain enzymes that are responsible for the antioxidant system, enabling the regulation of oxidative stress which depends on the intake of antioxidants and other food substances.
  • Vitamin D is essential for maintaining strong and healthy bones, teeth, and muscles. We can get it through foods such as eggs or fish, but also under the influence of sunlight. The metabolism of vitamin D is dependent on specific genetic variants that lead to vitamin D deficiency, which must be compensated by diet.

Nutrigenetic test is considered for all age groups (from 18 months of age) who have family members suffering from various metabolic disorders (diabetes, high cholesterol...) and healthy people who want to get a personalized healthy diet plan to prevent the development of diseases in the future. Testing is enough to be done once in a lifetime.

For more information, feel free to contact us by phone number +385 1 2867 400 or by e-mail info@stcatherine.com.

LIST OF ANALYZED GENES AND NON-CODING REGIONS:

ADRB2, CLOCK, GHRL, UCP1, FABP2, PPARG, APOA5, PLIN, MTNR1B, FADS1, FADS2, ADIPOQ, FTO, DRD2, ADH1B, GCKR, KLB, OPRM1, ADH1C, CHRNA3, CAT, GPX1, SOD2, COMT, SLC39A8, LONRF2, GIPR, RPL31P12, LOC101929710, KCTD15, SH2B1, BDNF-AS, DKK2, LINC01748, ADORA2A, HNMT, MCM6, ADD1, AGT, DOCK6, ANGPTL8, CELSR2, APOB, ABCG8, LIPC, NR1H3, SUGP1, APOE, TOMM40, SLC22A1, HMGCR, APOC1, DOCK7, SMARCA4, ZPR1, PCSK9, ABCC11, ZBTB38, CYP1B1, NQO1, TCF7L2, AGER, G6PC2, SLC2A2, CUBN, BCO1, FUT2, CYP2R1, GC, VDR, ST6GALNAC3, CLYBL, LRPPRC, OSBPL3, PLEKHB1, GBF1, TGFA, SEC16B, PHACTR1, ACER2, MYBPC3, NFIA-AS2, HFE, LOC107985840, ACTN3, CPNE5, GDF5, PRELID2, MS4A3, FUT6, CBS, MTR, MTHFR, MTHFD1, MTRR, IL-1 beta, TNF-alpha, IL-6, TMPRSS6, LINC02966, COL5A1, COL1A1.

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