Regenerative Orthopaedics and Tissue Engineering
ST. CATHERINE HOSPITAL IS “THE CENTER OF EXCELLENCE” FOR USE OF A CELL-FREE COLLAGEN TYPE I MATRIX (CaReS-1S) FOR THE THERAPY OF LARGER CARTILAGE DEFECTS IN THE KNEE JOINTS
CaReS-1S matrix technology is a new approach in the therapy of cartilage defects. Matrix technology represents 99.8%, native collagen with osmotic properties that stimulate the ingrowth of cells into the implant. In addition, this technology is helping migration of autologous cells from the surrounding tissue to the entire implant. Finally, migrated chondrocytes express collagen type II that is typical substance for hyaline cartilage.
Indications for application of CaReS-1S are: focal, full-layer cartilage defects) ICRS classification 3 and 4), defects without and with involvement of subchondral bone, defect size up to 8 cm2, patient age: 18-60 years, BMI <35, Osteochondritis dissecans.
Clinical studies with CaReS-1S matrix technology
Recent study demonstrates the high chondrogenic potential of the applied collagen gel, which might help to overcome the disadvantages inherent in conventional cartilage tissue engineering methods1. Gavenis and his collegues showed that a collagen gel plug intended for the treatment of focal cartilage lesions could promote chondrocyte in-growth and proliferation in vitro. They believe that this cell-free plug has the potential to become a device for the arthroscopic treatment of focal cartilage defects2. On the other hand Schüzler showed that the use of cell-free collagen type I matrix implants led to a significant and durable improvement in all the clinical and imaging scores investigated 4 years after implantation.
1.Schneider et al., A comparative study of 3 different cartilage repair techniques. Knee Surg Sports Traumatol Arthrosc. 2011;19(12):2145-52.
2.Gavenis et al., Cell-free repair of small cartilage defects in the Goemnger minipig: Which defect size is possible? K Gavenis et al. Knee Surg Sports Traumatol Arthrosc. 2011; 20 (11): 2307-2314.
3.Schüzler et al., Use of cell-free collagen type I matrix implants for the treatment of small cartilage defects in the knee: clinical and magnetic resonance imaging evaluation. Knee Surg Sports Traumatol Arthrosc. 2014;22(6):1270-6.